10 Best Oncology Billing Companies Every Provider Should Know

Oncology is one of the most significant and high-impact medical specialties in the United States. According to Cancer.org, there will be an estimated 2,041,910 new cancer cases and 618,120 cancer-related deaths in the United States for 2025. 

With such a high patient volume, oncology billing becomes extremely complex. This is because cancer care involves frequent prior authorizations and strict compliance with ever-changing payer guidelines. Due to these challenges, oncology practices face claim denial rates as high as 20%. 

Nowadays, oncologists increasingly rely on specialized companies with expertise in oncology billing services to manage the reimbursement processes. But finding a reliable partner can be challenging with so many billing vendors offering their services.That’s why this article highlights the Top 10 oncology billing companies in the U.S. for 2025. This guide offers you a quick overview of their strengths and services to help you choose the right partner for your oncology practice.

List of 10 Best Oncology Billing Companies in the U.S in 2025

Here are our top picks for the top oncology medical billing companies in the USA:

• Transcure
• Oncology Billing & Consulting Firm, LLC
• Radiation Business Solutions 
• Oncology Convergence, Inc
• US Global Medical Billing
• Medisys Data Solutions, Inc
• MedicotechLLC
• Plutus Health
• RC Billing
• NCG Medical 
• Altumed

1. Transcure

Transcure is the top-rated oncology medical billing company in the U.S., fully HIPAA-compliant and ISO 27001 certified. With almost two decades of specialized experience in cancer billing, Transcure provides end-to-end revenue cycle management for oncology practices. 

Our services cover the full scope of oncology care, including chemotherapy infusions, radiation therapy, immunotherapy, and targeted biologics. Transcure also specializes in prior authorizations, ensuring timely approvals for chemotherapy, radiation, immunotherapy, and imaging to avoid delays in patient care and reimbursements.
What sets Transcure apart is its compliance with the Oncology Care Model and insurance-specific regulations, including Medicare and Medicaid. We strictly follow CMS regulations and oncology coding guidelines for compliance and accuracy. Most importantly, our team has delivered up to 20% improvement in the financial performance of oncology practices that we’ve partnered with.

Attributes	Details
Experience	23 years
Key Strengths	Integration with 40+ Oncology EHR Software Free Oncology-specific credentialing and payer enrollment Robotic Process Automation (RPA) Oncology Denial Management Infusion services coding ICD-10 cancer staging documentation Oncology Procedure-Specific Coverage Dedicated oncology billing account manager Transparent pricing model (no hidden costs) Real-time reporting & dashboards
Specialty	40+ medical specialties, expertise in medical, surgical, pediatric, neurology, and radiation oncology
Client Base	Small to mid-sized oncology practices, Large Oncology Centers, Hospitals & Cancer Health Systems
Service Coverage	Head offices in New Jersey, Texas, and Florida; serves clients across 50 states

How Transcure Outperforms Other Oncology Billing Companies?

Another reason to choose Transcure is its outstanding performance metrics. Here are the numbers that highlight Transcure’s commitment to delivering excellent oncology medical billing services:

• 24 Accounts Receivable Days (Industry Average: 40 days)
• 99% Customer Retention (Industry Average: 85-90%)
• 98% First Pass Clean Claims Rate (Industry Average: 85-90%)
• Up to 20% Revenue Improvement (Industry Average:5-10%)
• 30% Reduction in Accounts Receivable (Industry Average: 15-25%)
• 96% Average Collection Rate (Industry Average: 85–90%)

2. Oncology Billing & Consulting Firm, LLC

Oncology Billing & Consulting Firm, LLC is a specialized medical billing and consulting company that serves Hematology-Oncology practices. Since 2003, OBCF has partnered with multiple oncology providers and has provided them with the latest reimbursement techniques and technology. 

OBCF stands out as a trusted partner in oncology billing due to its proven track record of 95–100% net collections. Moreover, OBCF uses advanced software combined with oncology-specific application support to ensure accurate claim submission.

Attributes	Details
Experience	22 years
Key Strengths	Denial reprocessing and appeals Monthly patient statements Insurance Verification & Authorizations Monitors payer fee schedules Coding of administration, drug, and diagnosis codes Chemo claim review
Specialty	Hematology & Oncology billing and consulting services
Client Base	Hematology Oncology physician practices
Service Coverage	Head office in New Jersey; Serves nationwide

3. RC Billing

RC Billing is a U.S.-based billing company, providing services for both standard and advanced oncology procedures. They offer full-service accounts receivable management services by handling daily billing, payment posting, denials, and appeals to ensure timely collections. 

Currently, the company provides billing services to over 350 oncology providers nationwide and processes billions in claims. Beyond billing, RC also offers comprehensive credentialing services, including enrollment with Medicaid, Medicare, and commercial payers.

Attributes	Details
Experience	22 years
Key Strengths	Annual SSAE-18 SOC 1 Type 2 audit Patient statement processing & collections Monthly and weekly financial reporting Electronic and Paper Claim Submissions Claim Scrubber Documentation audits
Specialty	Radiation and medical oncology, including proton therapy
Client Base	Cancer centers, radiation oncology practices, and medical oncology providers
Service Coverage	Head office in Texas; Serves nationwide

4. Oncology Convergence, Inc

Oncology Convergence is one of the well-known oncology billing companies in the U.S that is experienced in providing complete revenue cycle management services for cancer care providers. Within oncology, the company primarily specializes in medical oncology, radiation oncology, and gynecologic oncology.

In addition, Oncology Convergence has a team of expert coders who ensure accurate claim submission and specialize in coding for complex cancer treatments. This includes immunotherapy, targeted therapy, checkpoint inhibitors, biologics, and genetic therapies.

Attributes	Details
Experience	16+ years
Key Strengths	Real-time reporting & portal access Experienced coders for complex cancer drugs Medicare and commercial reimbursement Co-pay/Co-insurance Assistance Enrollment Expertise in the 340B drug discount program Reimbursement rate analysis
Specialty	Radiation oncology, medical oncology, and gynecologic oncology
Client Base	Small single specialty offices to large multi-specialty academic medical centers
Service Coverage	Head offices in Denver, Colorado, and Tempe; Provides services across the United States

5. Oncology Revenue Services

Oncology Revenue Services is consistently recognized for four consecutive years among the nation’s largest oncology revenue cycle management (RCM) firms by Modern Healthcare Magazine. The company is specifically known for its deep knowledge of oncology reimbursement systems and insurance rules.

Oncology Revenue Services has brought significant reduction in denial rates and maximized past and future reimbursements for practices they have partnered with. You must consider this company if you’re looking for an all-in-one oncology billing partner that offers full RCM, acquisition review and projection services, and cancer center development support.

Attributes	Details
Experience	17 years
Key Strengths	99% claims approval rate Medicare and Medicaid billing Oncology-specific Billing Specialists Integration with 30+ EHR software Contract Negotiation MIPS Quality Reporting & Services
Specialty	Radiation, infusion, chemotherapy, and hematology billing
Client Base	Hospital infusion centers, physician-based practices
Service Coverage	Head office in New York; Serves across the US

6. US Global Medical Billing

US Global Medical Billing is a professional billing company that provides complete revenue cycle management solutions specifically for oncology practices. The company has expertise in accounts receivable management, denial resolution, insurance verification, and oncology claims processing.

Unlike other oncology billing companies in the nation, US Global offers a free trial-based audit to identify gaps in practice performance and identify the reasons behind revenue loss. In addition to this, the company also supports providers with credentialing, helping them with CAQH profile setup and enrollment with maximum payers. 

Attributes	Details
Experience	10+ years
Key Strengths	Custom reporting Affordable tier-based pricing Patient Help Desk A/R clean-up Oncology Insurance Verification Coding audits
Specialty	40+ medical specialities; basic oncology procedures
Client Base	Physicians, solo providers, small & large oncology practices
Service Coverage	Oncology practices across the United States

7. Medisys Data Solutions, Inc

Medisys Data Solutions is also a prominent name in the list of oncology billing outsourcing companies. This company offers specialized billing solutions to address the complex challenges of oncology coding, claim management, and revenue cycle optimization.

They carefully follow the US compliance rules and stay updated with the changing rules to ensure the claims are accurate and are less likely to be denied. In case of claim denials, Medisys also has an expert denial management team that works on denied claims and resubmits them.

Attributes	Details
Experience	15 years
Key Strengths	Payment Posting & Secondary Billing Patient Insurance/Eligibility Verification Free Practice Analysis Patient Statement Preparation Maintains aging claims below 90 days Dedicated account managers
Specialty	35+ medical specialities; Standard Oncology Care
Client Base	Solo practitioners to large group practices
Service Coverage	Head office in Delaware; Provides services across the U.S.

8. Ambsi

Amsbi has positioned itself as a trusted partner in oncology medical billing that has a proven track record of error-free and denial-free claim submissions for oncology providers. They conduct regular staff training to ensure the billing specialists are well-versed with oncology-specific codes and reimbursement rules. 

Apart from that, the company simplifies the complex billing process for cancer care, including accurate documentation, timely claim submission, and effective denial management. Ambsi also has extensive knowledge of multiple insurance carrier processes, so they can easily handle claims from different insurance companies.

Attributes	Details
Experience	N/A
Key Strengths	Secure data management 24/7 billing support Automated Claims Processing Patient Portal Access Customizable Reporting HIPAA-compliant billing system
Specialty	32 specialities; basic Oncology billing services
Client Base	Hospitals, medical groups, and individual oncology practices
Service Coverage	Across the country

9. MedicotechLLC

MedicotechLLC is a U.S.-based oncology medical billing company that provides comprehensive solutions for chemotherapy and radiation therapy claims. The company ensures accurate billing practices, which helps oncology practices achieve a 92% first-time claim acceptance rate.

They also provide real-time reports for your oncology practice, revenue cycle performance, claim status, and key financial metrics. Plus, MedicotechLLC strictly follows HIPAA policies and ICD-10 standards in oncology billing to ensure regulatory compliance and confidentiality of patient data. 

Attributes	Details
Experience	5 years
Key Strengths	AAPC-certified coding specialists Patient insurance checks Statement generation Patient help desk services Free first-month billing audit Follows local insurance providers and payer policies
Specialty	7 specialities; common oncology treatments
Client Base	Healthcare providers, clinics, hospitals
Service Coverage	Head office in Florida; Services across the U.S.

10. Plutus Health

Plutus Health has a team of 1100+ oncology medical billers and coders who ensure accurate use of CPT codes while staying updated with CMS oncology billing guidelines. They also provide prior authorization and eligibility verification services to verify coverage and get timely approvals for treatments.

In addition, their patient support services help track copays and deductibles, generate accurate patient statements, and improve patient collections by 35%. When you partner with this company, they begin with a free RCM assessment to identify denial patterns and other cash flow gaps. 

Attributes	Details
Experience	15+ years
Key Strengths	AI-Enabled Financial Analytics RCM Audits Denial & AR Management Drug Formulary Buy & Bill Compliance AAPC-certified coders Generate patient statements
Specialty	20 specialities, including Surgical, Medical, Radiation oncology
Client Base	Small to mid-sized oncology practices, cancer centers & hospitals
Service Coverage	Head office in Texas; Provides services across the US

Conclusion

As discussed in this article, oncology is one of the most financially demanding specialties in healthcare. Oncology practices find it difficult to keep up with the huge number of cancer cases and complex billing requirements. And that’s when practices must think about partnering with an expert oncology billing company. 

All of the companies listed above bring specialized expertise to the table. But, if you’re looking for a proven leader with decades of oncology billing experience, advanced automation, and a record of increasing revenue, Transcure clearly stands out.  

Their oncology-focused RCM solutions, integration with 40+ EHRs, and industry-best performance metrics make them the ideal partner for small practices, cancer centers, and large health systems alike.