Top 10 Medical Billing Companies in Columbia, SC

Columbia is the capital of South Carolina and a major healthcare hub serving more than 850,000 residents across the Midlands region. The city has a strong mix of Medicare, Medicaid, and commercial insurance patients, which increases billing complexity for local practices. 

With large systems like Prisma Health and MUSC Health–Midlands operating alongside independent clinics, accurate coding and fast reimbursements are critical. As staffing shortages and payer rule changes continue, many providers rely on specialized medical billing companies in Columbia, SC. This listicle highlights some of the leading medical billing providers supporting healthcare practices in the region.

1. Transcure
2. Physician Services USA, LLC
3. Practolytics LLC
4. ResourceOne Medical Billing
5. Podiatry Services of SC, LLC
6. Newberry Medical Billing, LLC
7. 5 Star Billing Services
8. Lowcountry Billing Services
9. Medical Billing Center
10. Zmed Solutions LLC

1. Transcure

Transcure is a medical billing company in Nashville that combines expert billing with cutting-edge automation. We transform how practices manage revenue cycle management (RCM) using 7 dedicated AI agents under the supervision of 1100+ AAPC certified billers and coders. 

These agents automate repetitive tasks like insurance eligibility checks with ELIXA, claims scrubbing via CLAIR, and coding precision through CODIN. This use of the latest tech means our clients see meaningful results with many reporting up to 20% revenue growth within months.

With a focus on compliance and real-time billing insights, we help practices reduce denials to less than 1% and achieve 99.99% clean claim rates. Additionally, Transcure supports more than 40 EHR systems, including Epic, Cerner, athenahealth, eClinicalWorks, and NextGen.

Best For	Small Practices Hospitals and Health Systems Medical Group Practices Physicians from Every Specialty Urgent Care Centers Surgical Centers
Key Highlights	500+ provider clients served HIPAA-compliant medical billing services MIPS Reporting Free Consultation & Demo Complimentary Credentialing & Old AR Recovery Dedicated Account Management Daily, weekly, and monthly analytics reporting 30% Reduction in AR 99% Customer Retention 9% more Medicare reimbursements A/R days reduced to 24 MIPS and MACRA consulting services
Experience	23 years

2. Physician Services USA, LLC

Physician Services USA is a Columbia, South Carolina–based medical billing and practice management firm serving providers nationwide. They improve cash flow through end-to-end medical billing, collections, consulting, and revenue cycle management. 

With a hands-on approach and aggressive follow-up on unpaid claims, Physician Services USA focuses on long-term financial stability and operational efficiency for healthcare practices. The company also provides dedicated account managers to ensure personalized support and consistent communication.

Best For	Physicians, dentists, laboratories, FQHCs, and RHCs
Key Highlights	Specialized expertise in FQHC and RHC billing Free Practice analysis Full-service billing, collections, and revenue cycle management Physician/staff training services
Experience	23 years

3. Practolytics LLC

Practolytics is a full-service healthcare revenue cycle management (RCM) company providing end-to-end medical billing, coding, and financial optimization services to healthcare providers across the United States. With over 20 years of industry experience, the company supports more than 1,400 active providers across 31 states.

The company claims that partnering with them leads to a 15 to 20% revenue improvement in practice’s revenue. Moreover, they ensure patient data security by following the HIPAA regulations. 

Best For	Multi-speciality practices, including Urgent care, behavioral, and physical therapy.
Key Highlights	Support for over 28 medical specialities 97% first-pass claim ratio 7-day claim submission time Contract Negotiations and Credentialing
Experience	20 years

4. ResourceOne Medical Billing

ResourceOne Medical Billing, LLC is a medical billing agency Columbia working with all aspects of your practice to ensure accurate billing and maximum reimbursement. This company focuses on accurate charge capture, aggressive follow-up on unpaid claims, and customized financial reporting. 

Its certified coding team, high coding accuracy, and payer management expertise help practices maximize reimbursements and maintain long-term financial stability. Additionally, ResourceOne ensures 99.9% coding accuracy with the AAPC and AHIMA certification coding team. 

Best For	Solo practitioners, large multi-specialty practices, and hospitals
Key Highlights	Fast electronic insurance filing Fee schedule analysis and recommendations Customized monthly statistical reports MIPS reporting
Experience	27 years

5. Podiatry Services of SC, LLC

Podiatry Services of SC, LLC is a Columbia, South Carolina–based medical billing company specializing exclusively in podiatry billing services. Founded in 2002, the company brings decades of hands-on experience in medical claims management and focuses on accurate, first-time claim submission for faster reimbursements. 

With personalized service, web-based billing software, and free EMR integration, Podiatry Services of SC simplifies daily billing operations. Its end-to-end billing support helps podiatry practices of all sizes maintain steady cash flow.

Best For	Pharmacy, Family Practice, Pediatrics, Chiropractic, DME, and Podiatry practices
Key Highlights	Send Patient Statements on a Monthly Schedule Insurance Credentialing BBB-accredited business with an A+ rating Appeal all insurance denials
Experience	23 years

6. Newberry Medical Billing, LLC

Newberry Medical Billing, LLC is one of the best medical billing companies in Columbia, SC, providing patient billing, coding, and revenue cycle management services. The company supports family practice, diagnostic services, wound care, and therapy providers with efficient claims processing and accounts receivable management.

With continuous A/R monitoring, Newberry Medical Billing addresses denials promptly and communicates trends clearly. Their fast turnaround times, customized reporting, and reliable services make them a reputable company.

Best For	Family practice Diagnostic Services Wound Care Therapy Centers
Key Highlights	Experienced AAPC-certified coders Payer-specific expertise Clearinghouses Integration Deal with workers’ compensation cases
Experience	20 years

7. 5 Star Billing Services

5 Star Billing Services. is a U.S.-based professional medical billing company offering full-service and partial outsourcing solutions across all 50 states, including South Carolina. They specialize in RCM, including coding, claims submission, AR management, insurance collections, denial management, and reporting. 

The company also maintains compliance with HIPAA and other regulatory standards. Their services integrate with 20 EHR software, including AdvancedMD, Athena, and Kareo, which means practices can continue using their existing system.

Best For	Small to large healthcare practices seeking full or partial medical billing outsourcing.
Key Highlights	Billing expertise across 36 medical fields Conducts quarterly coding updates Performing system-based claims scrubbing Certified coders with in-depth knowledge of multi-specialty billing
Experience	30 years

8. Lowcountry Billing Services

Lowcountry Billing Services is a South Carolina–based EMS billing company with over 30 years of experience serving municipalities, private providers, and health systems. The company offers full-service billing solutions, including patient billing, claims processing, regulatory compliance, and revenue reporting. 

To date, Lowcountry has served 100+ agencies and collected over $2 billion in revenue. They offer expert guidance on compliance, audits, and documentation updates to ensure regulatory adherence.

Best For	Local Governments Private Providers Health Systems
Key Highlights	Revenue increased up to 2.5x for clients 24/7 real-time access to billing information Strong focus on compliance and patient-focused billing Aged Claims Management
Experience	35+ years

9. Medical Billing Center

Medical Billing Center (MBC) is a specialized billing company serving outpatient therapy practices, hospitals, health systems, and physician partnerships across the U.S. With over 22 years of experience, MBC focuses on optimizing revenue cycles so healthcare providers can focus on patient care. 

Their services include claims management, posted payments, and denial management, along with insurance verification, patient support, detailed reporting, and consulting. MBC partners with over 115 clinics nationwide and provides up-to-date guidance on payer regulations.

Best For	Therapy practices and Hospitals
Key Highlights	Custom reporting & monthly performance check-ins Free confidential billing assessment valued at $299 Focus on therapy and outpatient rehabilitation billing HIPAA privacy and security regulations
Experience	22 years

10. Zmed Solutions LLC

Zmed Solutions LLC is a medical billing company Columbia that provides HIPAA-compliant, end-to-end revenue cycle management (RCM) solutions. They cover everything from insurance verification and claim submission to denial management, patient billing, and secure reporting.

Their team provides free consultations, ongoing support, and performance analytics to improve collections and reduce A/R days. The company serves multiple states and healthcare specialties and is known for its 99% client retention rate.

Best For	Chiropractors, physical therapists, mental health providers
Key Highlights	First Free Consultation Experience in using almost every EHR Serves 35 States EHR, PM and Clearing House Setup
Experience	8 years

How Our Editors Selected the Top Medical Billing Companies in Columbia, SC?

Our editors compiled a list of the top medical billing companies in Columbia, SC through a systematic evaluation process focused on accuracy and relevance. We analyzed Google Maps profiles to gauge local presence, client base, and customer feedback, and also examined Yelp reviews and conducted SERP analysis to capture real experiences regarding billing accuracy, support quality, and issue resolution. 

Each company was further assessed based on the range of services, specialties served, compliance practices, and billing precision. The final ranking reflects overall performance, expertise, reliability, and the ability to enhance provider cash flow and operational efficiency.

What are the best medical billing companies in South Carolina?

The best medical billing companies in South Carolina are Transcure, Physician Services USA, LLC, and Practolytics LLC. These companies are renowned for their performance, specialty coverage, and technological capabilities. 

What are the benefits of outsourcing medical billing in Columbia, SC?

Outsourcing medical billing in Columbia, SC, helps healthcare providers improve cash flow, reduce claim denials, and stay compliant with state-specific payer rules. Experienced billing companies understand the requirements of SC based billing regulations. It also lowers operating costs by eliminating the need for in-house billing staff, training, and software. 

How to choose a medical billing company in Columbia, SC?

To choose a medical billing company in Columbia, SC, review Google and Yelp ratings, check client portfolios, and confirm experience in your specialty. Ensure the company understands SC payer rules, provides clear reporting, and offers transparent pricing to support long-term revenue growth.

What percentage do medical billers take in Columbia, SC?

Medical billers in Columbia, SC typically charge around 5–8% of net collections for full RCM services, depending on practice size and specialty. Transcure, however, offers a competitive 5% rate. This helps practices keep more of their revenue while benefiting from expert billing support and faster reimbursements

Which is the best medical billing company in Columbia, SC?

The best medical billing company in Columbia, SC, is Transcure, with dedicated AI agents handling core RCM steps like eligibility verification, claim scrubbing, and denial management. Their technology-driven approach and certified coders help practices achieve 99.99% clean claim accuracy and 1% denial rate. 

What are the five best medical billing companies in Columbia, SC?

The five best medical billing companies in Columbia, SC, include Transcure, Physician Services USA, LLC, Practolytics LLC, ResourceOne Medical Billing, and Podiatry Services of SC, LLC. These providers stand out for strong claims performance, specialty expertise, advanced technology, transparent pricing, and proven results.

What factors should I consider before hiring a medical billing company in Columbia, SC?

Before hiring a medical billing company in Columbia, SC, evaluate experience, state-specific payer knowledge, and specialty expertise. The right partner should understand SC Medicaid, Medicare, and local commercial insurers, and support your clinical specialty with accurate coding and denial management. Transcure meets all these criteria with proven RCM experience, specialty-focused workflows, and advanced technology.