Summary: Transcure is one of the best Oncology Billing Companies in the USA. Other top medical billing companies include Oncology Convergence, Inc, Oncology Billing & Consulting Firm, LLC, and Radiation Business Solutions.
Oncology is one of the most complex and high-stakes medical specialties in the United States. According to the American Cancer Society, approximately 2,114,850 new cancer cases and 626,140 cancer-related deaths are projected in 2026 alone, underscoring the critical importance of effective cancer care nationwide.
That volume puts enormous pressure on oncology billing. Cancer treatment requires frequent prior authorizations, precise coding, and constant adaptation to shifting payer guidelines. As a result, oncology practices face claim denial rates of up to 20%.
To manage this complexity, more oncologists are turning to specialized Oncology billing companies with deep expertise in oncology reimbursement. The challenge is knowing which companies actually deliver results.
This guide presents the top 10 oncology billing companies in the United States, with a clear breakdown of each company’s strengths and services to help you find the right fit for your practice.
| Company | Rating | Core Expertise |
|---|---|---|
Transcure
|
Rating:
★★★★★
4.9
★★★★★
|
Core Expertise: Supporting 40+ specialities, including Oncology billing. AI-powered Oncology RCM, 1,100+ AAPC-certified billers, 40+ EHR integrations, and near-zero claim denial rates. |
CHN Medical Billing
|
Rating:
★★★★★
4.5
★★★★★
|
Core Expertise: Coding, denial management, and specialised, cloud-based, or integrated Electronic Health Record |
PCH Health
|
Rating:
★★★★★
3.3
★★★★★
|
Core Expertise: AI-driven tools and certified coding specialists, automation, and Analysis |
Oncology Convergence, Inc
|
Rating:
★★★★★
3.9
★★★★★
|
Core Expertise: Oncology-specific revenue cycle management (RCM), providing billing, coding, and consulting services |
US Global Medical Billing
|
Rating:
★★★★★
4.0
★★★★★
|
Core Expertise: Revenue cycle management (RCM), consultancy for healthcare providers, and tech-driven billing |
Medisys Data Solutions, Inc
|
Rating:
★★★★★
4.4
★★★★★
|
Core Expertise: Reimbursements, reducing claim denials, and specialised software integration |
MedicotechLLC
|
Rating:
★★★★★
4.0
★★★★★
|
Core Expertise: Medical billing, Coding, and Credentialing for Healthcare providers |
Plutus Health
|
Rating:
★★★★★
4.5
★★★★★
|
Core Expertise: Optimise financial performance. Robotic process automation (RPA) and machine learning |
RC Billing
|
Rating:
★★★★★
3.0
★★★★★
|
Core Expertise: Medical and radiation oncology RCM |
NCG Medical
|
Rating:
★★★★★
3.8
★★★★★
|
Core Expertise: RCM, Medical coding, speciality coding & editing, Medical practice consulting, data analytics. |
1. Transcure
When we talk about the best Oncology medical billing companies in the US, Transcure is the ultimate choice. And the reasons are pretty obvious. First, it is HIPAA-compliant and ISO 27001 certified.
With over 20 years of specialised experience in cancer billing, Transcure delivers end-to-end revenue cycle management built specifically for oncology practices.
Our oncology billing services cover the full scope of cancer care, such as chemotherapy infusions, radiation therapy, immunotherapy, and targeted biologics. Transcure also handles prior authorisations, securing timely approvals for chemotherapy, radiation, immunotherapy, and oncology imaging. You will find no delays in patient care and no gaps in cancer care reimbursements.
What separates Transcure from other oncology billing companies is our knowledge of the Oncology Care Model and oncology-specific insurance regulations. The Medicare and Medicaid oncology billing is also completely covered. The team follows CMS oncology regulations and cancer-specific coding guidelines with precision, keeping every claim clean and compliant.
The results are extraordinary in Oncology practices partnered with Transcure have seen up to 20% improvement in financial performance.
| Attribute | Details |
|---|---|
| Experience | 23 years |
| Key Strengths |
|
| Specialty | 40+ medical specialties, expertise in medical, surgical, pediatric, neurology, and radiation oncology |
| Client Base | Small to mid-sized oncology practices, Large Oncology Centers, Hospitals & Cancer Health Systems |
| Service Coverage | Head offices in New Jersey, Texas, and Florida; serves clients across 50 states. |
How Transcure Outperforms Other Oncology Billing Companies
Transcure has outstanding performance metrics. Here are the numbers that highlight Transcure’s commitment to delivering excellent oncology medical billing services across the USA.
- 24 Accounts Receivable Days (Industry Average: 40 days)
- 99% Customer Retention (Industry Average: 85-90%)
- 98% First Pass Clean Claims Rate (Industry Average: 85-90%)
- Up to 20% Revenue Improvement (Industry Average: 5-10%)
- 30% Reduction in Accounts Receivable (Industry Average: 15-25%)
- 96% Average Collection Rate (Industry Average: 85-90%)
2. CHN Medical Billing

4.5
CHN Medical Billing is a US-based billing company serving specialty practices across the country. They bring solid experience in handling complex claims and revenue cycle management for healthcare providers.
On the oncology side, CHN Medical Billing supports cancer care practices with accurate coding for chemotherapy, radiation therapy, and immunotherapy services. They work with oncology-specific CPT and ICD-10 codes to reduce claim denials and speed up reimbursements.
| Attribute | Details |
|---|---|
| Experience | 17 years |
| Key Strengths |
|
| Specialty | 30+ medical specialties, expertise in medical, Neurosurgery, Gynecology, Urology, and Oncology |
| Client Base | Cancer patients, survivors, caregivers, healthcare providers, policymakers, and corporate partners |
| Service Coverage | Comprehensive national coverage across the United States, with a primary concentration of providers in the Northeast and New England regions |
3. PCH Health

3.3
PCH Health is a healthcare billing company serving medical practices across multiple specialties in the US. They focus on clean claim submission and reducing revenue loss for busy providers.
In oncology billing, PCH Health handles the heavy lifting. Coding for chemotherapy infusions, radiation therapy, and biologics. Their team works with oncology-specific CPT and ICD-10 codes to keep denials low and reimbursements moving.
| Attribute | Details |
|---|---|
| Experience | 20+ years |
| Key Strengths |
|
| Specialty | Focuses on Revenue Cycle Management (RCM) and administrative automation, including eligibility checking, medical coding, denial management, and underpayment analysis |
| Client Base | Serves over 100 insurance clients globally |
| Service Coverage | Operates nationally and internationally with over 120 service centers worldwide |
4. Oncology Convergence, Inc

3.9
Oncology Convergence, Inc. (OCI) is an oncology-only billing and revenue cycle management company. Operating out of Denver, Colorado, and Tempe, Arizona, OCI serves oncology practices of varying sizes across the US.
They bring 16 years of experience working with oncology practices nationwide, including some of the country’s largest health systems. Their services cover oncology billing, coding, and claims management, with specialization in Medicare and commercial reimbursement for medical oncology procedures. They also handle coding for cancer drugs, including immunotherapy, targeted therapy, checkpoint inhibitors, and biologics.
| Attribute | Details |
|---|---|
| Experience | 16+ years |
| Key Strengths |
|
| Specialty | Focuses on Hematology and Oncology, including medical oncology, radiation oncology, gynecologic oncology, and bone marrow transplants |
| Client Base | Ranges from small single-specialty private practices to large multi-specialty academic medical centers and hospital-based cancer programs |
| Service Coverage | Provides services nationwide across the United States. It operates primarily from main offices in Centennial, Colorado, and Tempe, Arizona |
5. US Global Medical Billing

4.0
US Global Medical Billing is a US-based billing company that works with oncology practices of all sizes. Solo providers, small groups, large practices. They offer end-to-end revenue cycle management and oncology billing services built around the specific needs of cancer care providers.
On the oncology side, their expertise covers accounts receivable management, denial resolution, insurance verification, and oncology claims processing. US Global offers a free trial-based audit to identify gaps in practice performance and pinpoint the reasons behind revenue loss. That is not something every billing company puts on the table upfront.
| Attribute | Details |
|---|---|
| Experience | 10 years |
| Key Strengths |
|
| Specialty | 40+ medical specialities; basic oncology procedures |
| Client Base | Physicians, solo providers, small & large oncology practices |
| Service Coverage | While based in Sacramento, California, it provides services nationwide across the United States |
6. Medisys Data Solutions, Inc

4.4
Medisys Data Solutions, Inc is a Delaware-based medical billing company serving multiple specialties across the US. Oncology is one of their focused service areas, and they treat it differently from general billing work. Their oncology billing covers everything from filing clean claims to collecting maximum revenue.
For oncology specifically, their services span ICD-10, CPT, and HCPCS coding by certified oncology billing professionals, payment posting with EOB and ERA reconciliation, denial management, and regulatory compliance monitoring, including Medicare changes and RO-APM model updates.
| Attribute | Details |
|---|---|
| Experience | 15 years |
| Key Strengths |
|
| Specialty | 35+ medical specialities; Standard Oncology Care |
| Client Base | Solo practitioners to large group practices |
| Service Coverage | Head office in Delaware; Provides services across the U.S. |
7. MedicotechLLC

4.0
MedicotechLLC is a U.S.-based oncology medical billing company that provides comprehensive solutions for chemotherapy and radiation therapy claims. The company ensures accurate billing practices, which helps oncology practices achieve a 92% first-time claim acceptance rate.
They also provide real-time reports for your oncology practice, revenue cycle performance, claim status, and key financial metrics. Plus, MedicotechLLC strictly follows HIPAA policies and ICD-10 standards in oncology billing to ensure regulatory compliance and confidentiality of patient data.
| Attribute | Details |
|---|---|
| Experience | 5 years |
| Key Strengths |
|
| Specialty | 7 specialities; common oncology treatments |
| Client Base | Healthcare providers, clinics, hospitals |
| Service Coverage | Head office in Florida; Services across the U.S. |
8. Plutus Health

4.5
Plutus Health has a team of 1600 oncology medical billers and coders who ensure accurate use of CPT codes while staying updated with CMS oncology billing guidelines. They also provide prior authorization and eligibility verification services to verify coverage and get timely approvals for treatments.
In addition, their patient support services help track copays and deductibles, generate accurate patient statements, and improve patient collections by 35%. When you partner with this company, they begin with a free RCM assessment to identify denial patterns and other cash flow gaps.
| Attribute | Details |
|---|---|
| Experience | 15+ years |
| Key Strengths |
|
| Specialty | 20 specialities, including Surgical, Medical, Radiation oncology |
| Client Base | Small to mid-sized oncology practices, cancer centers & hospitals |
| Service Coverage | Head office in Texas; Provides services across the US |
9. RC Billing

3.0
RC Billing is an oncology-only billing company. Their entire operation is built around revenue cycle management for cancer centers, medical oncology, radiation oncology, and proton therapy. That level of focus is rare. And for oncology practices, it matters.
On the services side, their team handles everything from charge entry and daily claim submissions to detailed payment posting, denial resolution, and month-end financial reconciliation. They also offer credentialing services, including enrollment with Medicaid, Medicare, and commercial payers.
| Attribute | Details |
|---|---|
| Experience | 20+ Years |
| Key Strengths |
|
| Specialty | Exclusive focus on Oncology, including medical oncology, radiation oncology, infusion services, and proton therapy |
| Client Base | Serves over 350 oncology providers across the United States |
| Service Coverage | National coverage across the United States with headquarters in Cedar Park, Texas |
10. NCG Medical

3.8
NCG Medical is a Florida-based billing company that has been helping medical practices streamline workflows, reduce billing errors, and increase revenue since 1979. They serve multiple specialties. In oncology, their focus sits specifically on radiation oncology billing. That is where their depth shows.
Their certified coders, MBAs, and CPAs handle automated workflows built for radiation oncology, covering both standalone practices and hospital-based physician billing.
| Attribute | Details |
|---|---|
| Experience | 40 Years |
| Key Strengths |
|
| Specialty | Supports oncology as part of its multi-specialty portfolio, but has a deeper concentration in fields like Dermatology, Orthopedics, and Urology |
| Client Base | Targets small-to-midsized independent private practices and multi-specialty physician groups |
| Service Coverage | Provides nationwide service across the United States. Their corporate headquarters is located in Winter Park, Florida |

Which is the Best Oncology Billing Company in the USA?
Transcure stands out as the best oncology billing company in the USA. With 23 years of experience, a 98% first-pass clean claim rate, and only 24 AR days on average, the numbers speak for themselves. They cover everything from chemotherapy coding to prior authorizations, all under one roof.
Which are the Best Medical Billing Companies in the USA?
When it comes to the best medical billing companies in the USA, three names rise to the top.
-
- Transcure leads the pack. A 99% customer retention rate, AI-powered RCM, and 1,100+ AAPC-certified billers make it the strongest all-around choice for practices of any size.
-
- CBS Medical comes in strong with AI-enabled analytics and a team equally capable of handling complex oncology claims and denial management.
-
- Med USA rounds out the top three with solid specialty depth, especially for oncology, neurosurgery, and gynecology practices.
Which Oncology EMR Software Do Practices Use?
The following are the top EMR software for oncology practices:
-
- Flatiron Health (OncoEMR) is purpose-built for oncology. It connects clinical documentation directly to billing, which significantly reduces coding errors.
-
- Epic is the most widely adopted system across large cancer centers and academic hospitals. Its billing module handles complex oncology workflows, though it requires experienced coders to maximize it.
-
- Modernizing Medicine (modmed) is gaining traction in smaller oncology and hematology practices. It offers robust automation features and integrates well with third-party billing partners such as Transcure.
How Can USA Practices Pick the Best Oncology Billing Companies?
-
- Check their oncology-specific experience. General billing knowledge is not enough. Chemotherapy drug billing, radiation therapy coding, and immunotherapy claims all follow different rules. Ask how many oncology practices they currently serve.
-
- Ask about their clean claim rate. Anything below 95% should raise a red flag. The industry average sits around 85-90%. The best companies like Transcure hit 98%.
-
- Look at their AR days. The longer your claims sit unpaid, the worse your cash flow. The industry average is 40 days. Aim for a partner that keeps it under 30.
-
- Confirm they handle prior authorizations. In oncology, prior auth denials are one of the biggest revenue killers. Your billing company should manage this proactively, not reactively.
-
- Verify compliance certifications. HIPAA compliance is non-negotiable. ISO 27001 certification is a strong bonus for practices handling sensitive cancer patient data.
-
- Ask for a free audit. Several top companies offer this upfront. It tells you exactly where your revenue is leaking before you sign anything.
What Certifications Does Transcure Oncology Have?
-
- HIPAA Compliant confirms that all patient data handling meets federal privacy and security requirements. For cancer care practices, where patient records are especially sensitive, this is the baseline.
-
- ISO 27001 Certified goes further. This is an internationally recognized information security standard. It means Transcure has formal systems in place to protect data at every level, not just at the surface.
Their billing team also includes 1,100+ AAPC-certified coders, the gold standard for medical coding professionals in the US.