Top 10 Medical Billing Companies in Sioux Falls for 2026

Healthcare services in Sioux Falls continue to expand, with more clinics, physician groups, and specialty providers serving patients throughout the region. Medical billing has become more challenging, with providers facing strict payer requirements, frequent coding updates, and ongoing compliance demands.

Managing these tasks in-house can strain staff and delay reimbursements, especially for smaller and mid-sized practices. To address these issues, many Sioux Falls providers are partnering with professional medical billing companies that bring expertise, accuracy, and efficiency to the revenue cycle.

Reliable medical billing companies like Transcure and Midwest Medical Billing supports financial stability and growth of practices. This article features the top 10 medical billing companies in Sioux Falls.

1. Transcure
2. Midwest Medical Billing
3. Medical Billing Partners
4. Resolve Medical Billing
5. SMB Medical Billing
6. West River Medical Billing
7. Medical Billers and Coders (MBC)
8. Medisys Data Solutions
9. CBI-RCM
10. HMS USA

1. Transcure

Transcure is a top medical billing company in Sioux Falls that blends certified billing expertise with AI-powered automation to manage critical stages of the RCM process. The company deploys seven specialized AI agents to support billing operations, including eligibility verification, claim scrubbing, denial prioritization, and follow-up.

Moreover, we automate routine tasks and work alongside more than 1,100 certified billers and coders. Transcure reduces manual errors and accelerates reimbursements for Sioux Falls-based practices.

Our HIPAA- and ISO-aligned processes ensure compliance and accuracy while easing administrative workloads. Surgical centers and hospitals working with Transcure report up to a 20% increase in collections and faster AR recovery, averaging 24 days.

Best For	AI-driven RCM with hands-on human oversight, especially in multi-specialty and multi-site clinics.
Key Highlights	Expertise In ICD-10/11 & CPT Codes Real-Time Reports & Analytics CMS And State Rules Compliance Less Than 1% Denial Rate MIPS Consultation Services Integrates Effortlessly With Major EHRs
Founded In	2002

2. Midwest Medical Billing

Midwest Medical Billing is the best medical billing company in Sioux Falls for practices needing transparent, reliable insurance billing. They specialize in electronic claims submission, denial management, and credentialing support.

Moreover, their dedicated account directors oversee eligibility checks, ERA posting, and payer follow-ups. Daily claim processing ensures steady cash flow and fewer reimbursement delays. Web-based reporting gives practices real-time access to AR and payment status.

Best For	Medical, mental health, therapy-based practices
Key Highlights	Monthly AR Tracking Financial Performance Reports HIPAA Compliant Web-Based Billing
Founded In	1998

3. Medical Billing Partners

Medical Billing Partners is a trusted medical billing outsourcing company serving practices seeking hands-on, personalized billing support. They focus on claim submission, payment posting, and patient billing services.

The team manages payer follow-ups, denied claims, and formal appeals. Credentialing services help providers contract correctly and avoid reimbursement delays. They primarily support mental health and therapy-based practices. Their tiered pricing model fits practices of different sizes and billing volumes.

Best For	Mental health and outpatient practices need end-to-end RCM support
Key Highlights	Electronic claim submission Active follow-up AR balance reporting Payment posting without EOB handling
Founded In	2000

4. Resolve Medical Billing

Resolve Medical Billing is an experienced outsourced medical billing company in Sioux Falls that helps practices regain control of reimbursement. They deliver contracted medical billing, insurance credentialing, and billing consultations.

The team works directly within existing EHR systems for accurate claim handling. Monthly aging reports track AR status with detailed follow-up notes. Patient statements are issued monthly with flexible payment plan support.

Best For	Small to mid-sized practices need accurate billing and consistent claim follow-up.
Key Highlights	Monthly aging reports AR status reports Patient billing support State Rules Compliant
Founded In	2019

5. SMB Medical Billing

SMB Medical Billing is a trusted medical billing firm in Sioux Falls, providing specialized billing solutions for multi-specialty practices. They focus on outsourced medical billing, revenue cycle management, and medical claim management.

The team handles claim submission, denial management, and patient billing with precision. EHR integration ensures seamless workflows without disrupting existing systems. Founded with expertise in podiatry billing, they now support surgery centers, chiropractic, primary care, and plastic surgery practices.

Best For	Practices needing specialized, accurate, and efficient billing with full claim lifecycle management
Key Highlights	EHR integration with Talon Software Compliance monitoring Dedicated account managers Flexible payment plan options
Founded In	2010

6. West River Medical Billing

West River Medical Billing is a reliable medical billing agency in Sioux Falls serving practices across South Dakota and nearby states. They provide medical billing, medical coding, and provider credentialing services.

Moreover, the team files claims for Medicare, Medicaid, and major commercial payers. Additionally, their coding follows current ICD-10 guidelines to reduce errors and denials. The agency emphasizes accurate reimbursement and ethical service.

Best For	Family medicine, OB/GYN, therapy, and EMS practices
Key Highlights	Electronic Claim Filing Credentialing Denied Claim Follow-Up Patient Statements
Founded In	2018

7. Medical Billers and Coders (MBC)

Medical Billers and Coders is a trusted medical billing provider in Sioux Falls, supporting practices across South Dakota. With over 25 years of experience, MBC delivers full-cycle revenue cycle management services.

Their team specializes in rehab billing, addressing complex coverage rules and frequent payer ambiguities. Local billers and coders stay aligned with changing state and federal billing regulations. MBC helps practices reduce AR days, limit denials, and improve collections through structured RCM workflows.

Best For	Rehab centers and multi-specialty practices need advanced RCM support and compliance-focused billing
Key Highlights	Strong Payer Follow-Up Sensitive Patient Communication Full RCM Outsourcing Monthly Financial Reporting
Founded In	1999

8. Medisys Data Solutions

Medisys is a reliable medical billing company based in Sioux Falls, serving practices across South Dakota. They provide end-to-end medical billing, coding, credentialing, and RCM services. Their team focuses on customized workflows for small, mid-sized, and large practices.

Moreover, Medisys combines local billing knowledge with advanced technology to improve cash flow. Transparent reporting helps providers track performance and make informed financial decisions.

Best For	Practices seeking customized billing support with strong compliance and reporting
Key Highlights	Real-Time Financial Reporting Tailored Billing Solutions Free Practice Analysis AR Follow-Up
Founded In	2018

9. CBI-RCM

CBI-RCM is recognized as one of the best medical billing companies in Sioux Falls, delivering fully U.S.-based revenue cycle services. They offer comprehensive medical billing, credentialing, compliance, and accounting solutions under one roof.

The company partners closely with practices to improve reimbursements while maintaining strict regulatory compliance. Their certified team brings decades of experience across multiple specialties and healthcare organizations.

Best For	Practices seeking an all-in-one billing, compliance, and accounting partner
Key Highlights	Reimbursement Gap Analysis Provides Denial Appeals Long-Term Client Partnerships Complex Multi-Specialty
Founded In	2009

10. HMS USA

HMS USA is a top medical billing company in Sioux Falls, delivering payer-focused RCM solutions that drive measurable results. The team blends local South Dakota billing insight with performance-based pricing and transparent reporting.

Practices benefit from faster AR resolution, fewer denials, and secure onboarding that avoids workflow disruption. With modular services and dedicated account management, HMS USA supports sustainable revenue growth across specialties.

Best For	Practices seeking fast AR cleanup, denial reduction, and performance-based medical billing support.
Key Highlights	Dedicated Regional Account Managers Built-In Revenue Audits Scalable Service Model Local Payer Intelligence
Founded In	2019

How Our Editors Selected the Top Medical Billing Companies in Sioux Falls

Our editors conducted extensive research to identify the leading medical billing companies in Sioux Falls. Local business listings and Google My Business profiles were analyzed for visibility and credibility. Customer reviews from platforms like Yelp and industry-specific forums were evaluated. Only consistently reliable, high-performing companies serving Sioux Falls healthcare providers were included in the final list.

What are the Best Medical Billing Companies in South Dakota?

Transcure is recognized as one of the top medical billing companies in South Dakota, along with West River Medical Billing LLC, Maximum Medical Billing Services, DT-Trak Consulting, and PrimeCare Medical Billing Services LLC. These leading firms provide full revenue cycle management, insurance verification, and specialty-focused billing services, helping healthcare practices across South Dakota optimize reimbursements, reduce denials, and maintain consistent, predictable revenue.

What are the Benefits of Outsourcing Medical Billing in Sioux Falls?

Outsourcing medical billing in Sioux Falls helps practices reduce coding errors, lower denial rates, and ensure timely claim follow-ups. It eliminates the costs of hiring in-house staff, improves accounts receivable efficiency, boosts reimbursements, ensures regulatory compliance, and allows providers to focus on delivering quality patient care while maximizing overall revenue performance.

What Percentage do Medical Billers Take in Sioux Falls?

Medical billing companies in Sioux Falls typically charge between 6% and 10% of monthly revenue collected, though some offer per-claim pricing options. For example, Transcure provides additional services such as credentialing, audit support, and ongoing compliance guidance at a 5% rate, helping practices boost revenue while keeping overall billing costs predictable and manageable.

Which is the Best Medical Billing Company in Sioux Falls?

Transcure is widely recognized as Sioux Falls’s top medical billing company, providing AI-powered revenue cycle management, credentialing, and specialty-focused billing services. Other leading firms include Midwest Medical Billing, Medical Billing Partners, Resolve Medical Billing, and SMB Medical Billing, all of which help providers minimize denials, maximize reimbursements, and maintain smooth, efficient revenue cycles across multiple medical specialties.

What are the Five Best Medical Billing Companies in Sioux Falls?

1. Transcure
2. Midwest Medical Billing
3. Medical Billing Partners
4. Resolve Medical Billing
5. SMB Medical Billing

What Factors Should I Consider Before Hiring a Medical Billing Company in Sioux Falls?

When hiring a medical billing company in Sioux Falls, consider their experience in your medical specialty, use of advanced billing systems, and strict HIPAA compliance. Evaluate their success in reducing claim denials, transparency in reporting, responsiveness of client support, and overall ability to streamline revenue cycle management for consistent and reliable practice reimbursements.