Overview

The most awaited yearly changes for CPT codes 2025 have finally been announced by AMA. There are 420 overall updates in the AMA CPT 2025 code set, including 270 new codes, 112 deletions, and 38 revisions. These changes reflect rapid advancements in various fields of medicine, particularly in proprietary lab analyses, which account for 37% of new codes, driven mainly by novel genetic testing. Additionally, Category III CPT codes, which represent emerging medical services, account for nearly a third of the new codes.

This blog will provide a simple and clear breakdown of what’s changing in the medical billing and coding world in 2025. We’ll uncover all the major new procedures that have been added to the CPT 2025 code set, codes that have been revised for more accurate billing, and codes that have been deleted. These changes are important for medical practices to ensure accurate billing and compliance with new coding standards set by AMA for the CY 2025.

The New Major CPT Codes 2025 Added

Code Description	Category/Specialty
MRI-monitored transurethral ultrasound ablation (TULSA)	Radiology
MRI Guided High Intensity Focused Ultrasound (MRgFUS)	Radiology, Transcranial Doppler
Transcranial Doppler	Radiology
Percutaneous RF Ablation of Thyroid	Radiology/Endocrinology
Fascial Plane Blocks (FPB)	Anesthesiology/Pain Management
Telemedicine Services (17 new codes)	E/M – Telemedicine
MR Examination Safety Procedures	Radiology/Diagnostic Imaging
Virtual Check-in code	E/M – Telemedicine
0477U – Drug Metabolism for Psychiatry	Psychiatry/Pharmacogenomics
0485U – Oncology (Solid Tumor) Cell-Free DNA and RNA	Oncology/Genomics
0482U – Obstetrics (Preeclampsia) Biochemical Assay	Obstetrics/Endocrinology
0480U – Infectious Disease (Metagenomic Sequencing)	Infectious Disease/Diagnostics
0516U – Pharmacogenomic Drug Metabolism Testing	Pharmacogenomics/Precision Medicine

The Revised CPT Codes 2025

There are 38 total revisions for 2025 CPT codes. All these codes are revised in order to meet the advancements in the field of medicine and to provide better care. These codes will define the procedures more comprehensively so providers can get rightful reimbursements. Here is the list of the most important revised CPT codes for 2025:

• 64486: Transversus abdominis plane (TAP) block; unilateral, injection

• 64487: Transversus abdominis plane (TAP) block; unilateral, continuous infusion

• 64488: Transversus abdominis plane (TAP) block; bilateral, injection

• 64489: Transversus abdominis plane (TAP) block; bilateral, continuous infusion

• 93893: Transcranial Doppler study of the intracranial arteries to detect emboli (blood clots)

• Guidelines: Vascular Procedures Guidelines revised (code 75774)

• 0248U: Oncology, spheroid cell culture in a 3D microenvironment, 12-drug panel, brain- or brain metastasis–response prediction for each drug

• 0403U: Oncology (prostate), mRNA gene expression profiling of 18 genes from first-catch urine, with results reported as a percentage indicating the likelihood of detecting clinically significant prostate cancer

• 0615T: Automated analysis of binocular eye movements without spatial calibration, including disconjugacy, saccades, and pupillary dynamics for the assessment of concussion, with interpretation & report

• 90661: Influenza vaccine, trivalent (ccIIV3), derived from cell cultures, subunit, preservative and antibiotic-free, 0.5 mL dosage, for intramuscular use

• 93893: describes venous-arterial shunt detection using intravenous microbubble injection

• 64486-64489: For detailed descriptions for transverse abdominis plane (TAP) blocks, both unilateral and bilateral, by injection or continuous infusion

The CPT Codes 2025 Set to be Deleted

In 2025, there will be 112 deletions from CPT codes. These deletions are made to update the coding system and delete the codes for obsolete or updated procedures. These updates help match the latest medical technology and improve patient care. They make it easier to describe what procedures are done, so doctors get paid correctly. Here’s a list of the most important deleted CPT codes for 2025:

• 0398T: Magnetic resonance image-guided high-intensity focused ultrasound (MRgFUS)

• 93890: Transcranial Doppler study of the intracranial arteries, focusing on vasoreactivity

• 99441: Telephone evaluation and management service lasting 5-10 minutes

• 99442: Telephone evaluation and management service (11-20 minutes)

• 99443: Telephone evaluation and management service (21-30 minutes)

• 0078U: Pain management (opioid-use disorder) genotyping panel testing for 16 common variants (e.g., ABCB1, COMT, DAT1, DBH, DOR, DRD1, DRD2, DRD4, GABA, GAL, HTR2A, HTTLPR, MTHFR, MUOR, OPRK1, OPRM1) using a buccal swab or other germline tissue sample. The results are reported as either a positive or negative risk for opioid use disorder

• 0167U: Gonadotropin, chorionic (hCG), immunoassay with direct optical observation, blood

• 0396U: Obstetrics (pre-implantation genetic testing), evaluation of 300000 DNA single-nucleotide polymorphisms (SNPs) by microarray, embryonic tissue, algorithm reported as a probability for single-gene germline conditions

• 75600-75756: Angiography

• 36215-36248: catheterization

• 93890: For vasoreactivity study with the associated procedures being rolled into other updated codes

CPT 2025 Code Set Retained for Another 5 Years

The new CPT codes list for 2025 also has some codes that are old and retained for use till 2025. You can find the most important retained codes for 2025 in the list below and streamline your coding to get reimbursed properly:

• 0071T: Ultrasound ablation of uterine fibroids, MR guidance, less than 200 cc

• 0072T: Ultrasound ablation of uterine fibroids, MR guidance, 200 cc or more

• 0075T: Placement of vertebral artery stent, initial vessel, with imaging

• +0076T: Placement of additional vertebral artery stent, with imaging (each extra vessel)

• 0200T: Unilateral sacral augmentation (sacroplasty) with balloon/device, includes imaging and biopsy

• 0201T: Bilateral sacral augmentation (sacroplasty) with balloon/device, includes imaging and biopsy

• 0554T: Bone strength and fracture risk assessment using CT scan data, including interpretation

• 0555T: Bone strength and fracture risk assessment using CT scan data, data retrieval

• 0556T: Bone strength and fracture risk assessment using CT scan data, risk assessment

• 0557T: Bone strength and fracture risk assessment using CT scan data, interpretation

• 0558T: CT scan for biomechanical analysis

• 0559T: 3D-printed anatomical model from image data, first component

• +0560T: 3D-printed anatomical model from image data, each additional component

• 0561T: 3D-printed anatomical guide from image data, first guide

• +0562T: 3D-printed anatomical guide from image data, each additional guide

Conclusion

The changes carried out in medical billing codes will be effective from October 1, 2024, and some on January 1, 2025. These updates introduce some key changes in the way billing and coding are done. It is very important to be aware of the changes in the CPT codes 2025 so that your billings will be appropriate and follow the new rules. Whether one practices radiology, urology, endocrinology, or pain management, knowledge of these updates will go a long way in improving your billing while ensuring better service delivery to your patients. It will also put your mind at rest that your practice will be running smoothly and your revenue is fully protected.

Staying updated with the new codes and regulations has always been a complication for providers and their in-house staff. So, it is always beneficial to outsource medical billing companies for they stay updated and alert about all the changes that come in the world of medical codes and billing. You can consult with billing experts at Transcure, as we offer decades of expertise with the help of 1100+ vigilant medical billers and coders.

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