Summary: “The best ASC billing companies include Transcure, which delivers AI-powered billing with 99% clean claim rates, followed by Serbin Medical Billing, Dastify Solutions, Medical Healthcare Solutions, ClaimCare, Wise Medical Billing, Surgical Information Systems, Sunshine Billing, in2itive Business Solutions, and Altruis.”
ASCs handle a major share of U.S. outpatient surgeries, performing upto 70% of outpatient cases. According to Colliers, revenues will increase to $57 billion by 2030, indicating a shift of higher-acuity procedures toward outpatient settings. With this increasing burden, surgery centers need specialized ASC billing services to manage their billing and coding.
However, ASC billing remains complex, with an average claim denial rate of 10–15%. Many ASC practices fail to rework up to 60% of these denials due to limited staffing and resources, making outsourcing ASC billing inevitable.
In this article, we will enlist top 10 ASC billing companies in the US. From a small practice struggling with staffing to a high-volume procedure practice aiming to reduce denials, this list will help you find the best ASC billing company for your practice.
Table of Contents
ToggleTop 10 ASC Billing Companies in the USA
| # | Company | Rating | Best For |
|---|---|---|---|
| 1 | Transcure |
Rating: ★★★★★ 5.0★★★★★ |
Best For:AI-enhanced, full-service ASC billing with denial reduction and underpayment recovery |
| 2 | Serbin Medical Billing |
Rating: ★★★★★ 5.0★★★★★ |
Best For:ASCs looking for a U.S.-based revenue cycle partner with dedicated RCM teams |
| 3 | Dastify Solutions |
Rating: ★★★★★ 4.8★★★★★ |
Best For:ASCs needing structured billing workflow support with AAPC/AHIMA-certified coders |
| 4 | Medical Healthcare Solutions |
Rating: ★★★★★ 5.0★★★★★ |
Best For:Full-cycle billing support with customized workflows and detailed analytics |
| 5 | ClaimCare |
Rating: ★★★★★ 4.1★★★★★ |
Best For:Experienced, full-cycle billing with broad payer knowledge across all 50 states |
| 6 | Wise Medical Billing |
Rating: ★★★★★ 4.9★★★★★ |
Best For:Reliable billing support with structured RCM workflows and HIPAA-compliant processes |
| 7 | Surgical Information Systems |
Rating: ★★★★★ 3.3★★★★★ |
Best For:Enterprise-grade RCM with software, billing, coding, and transcription under one roof |
| 8 | Sunshine Billing |
Rating: ★★★★★ 3.6★★★★★ |
Best For:ASCs seeking full billing cycle support with dedicated specialists |
| 9 | in2itive Business Solutions |
Rating: ★★★★★ 3.2★★★★★ |
Best For:Technology-enabled, full-cycle RCM partner that integrates into existing workflows |
| 10 | Altruis |
Rating: ★★★★★ 3.2★★★★★ |
Best For:Full-cycle RCM with RetroPay services to recover underpayments and denied claims |
1. Transcure
Transcure provides dedicated ASC billing and revenue cycle management services tailored to ambulatory surgery centers. Unlike general billing firms, we use AI-powered agents and certified ASC coders to handle every part of the revenue cycle. Our teams know how to apply the correct CPT, HCPCS, and facility-specific modifiers, helping your ASC avoid costly coding errors and denials.
This approach helps you achieve 99% clean claim rates and 80% reductions in denials within the first 90 days. By ensuring claims align with the CMS ASC Covered Procedures List and modifier rules, Transcure boosts the collection rate to over 96%.
Practices report up to 20% revenue improvement with reduced denials and faster payments. Our teams also reduce A/R by at least 30%, improving cash flow consistency for surgery centers that handle GI, orthopedics, ophthalmology, and pain procedures.

| Best For | Ambulatory surgery centers needing AI-enhanced, full-service ASC billing |
|---|---|
| ASC Specialties Supported | GI, Orthopedics, Ophthalmology, ENT, Pain Management, and More |
| Key Highlights |
|
| Compliance & Certifications |
|
| Founded In | 2002 |
2. Serbin Medical Billing
Serbin Medical Billing specializes exclusively in ambulatory surgery center (ASC) billing, with a personalized team model tailored to each center’s needs. With 30+ years of industry experience, Serbin provides dedicated teams for coding, charge posting, clean claim submission, payment posting, follow-up, patient billing, and comprehensive reporting.
They assign a dedicated RCM team to every client, which helps improve communication, accuracy, and payer relationships. As a result, centers see fewer denials, faster collections, and clearer revenue insights. Serbin also offers value-added services, such as fee-schedule support at no extra cost, helping ASCs strengthen internal operations and long-term financial stability.
| Best For | ASCs looking for a U.S.-based revenue cycle partner |
|---|---|
| ASC Specialties Supported | Surgery centers of all types |
| Key Highlights |
|
| Founded In | 2016 |
3. Dastify Solutions
Dastify Solutions is an ASC billing provider offering ASC billing focused on ambulatory surgery centers and outpatient procedures. Their team of AAPC- and AHIMA-certified coders manages everything from charge capture and eligibility checks to clean claim submission, helping ASCs reduce claim errors and improve cash flow.
Dastify’s specialized workflows and real-time analytics help centers achieve higher net collection rates up to 93%. With up to 20% revenue improvement, your practice experiences fewer resubmissions and faster payments for facilities. They focus on ASC-specific coding, secure HIPAA-compliant operations, and seamless integration with major EHR/EMR systems, which ensures compliance with CMS and payer rules.

| Best For | ASCs needing structured billing workflow support |
|---|---|
| ASC Specialties Supported | Orthopedics, GI, Pain Management, Ophthalmology |
| Key Highlights |
|
| Founded In | 2024 |
4. Medical Healthcare Solutions
Medical Healthcare Solutions offers ambulatory surgery center (ASC) billing and revenue cycle services to streamline ASC claims processing. Their ASC billing offering covers everything from patient registration and insurance verification to claims submission, and reporting/analytics to ensure smoother revenue cycles.
Their tailored solutions fit the unique workflows of each ASC and ensure compliance with billing regulations. This frees internal staff and helps administrators focus on surgical care rather than billing details. With detailed analytics and reporting, practices get better visibility into revenue trends and outstanding receivables.
| Best For | ASCs seeking full-cycle billing support with customized workflows |
|---|---|
| ASC Specialties Supported | Orthopedics, Gastroenterology, Eye/ENT, and other surgical center specialties |
| Key Highlights |
|
| Founded In | 1991 |
5. ClaimCare
ClaimCare is an ASC billing firm that provides services to help ASCs improve collections and reduce administrative burden. Many surgery centers lose more than 20% of potential revenue when billing isn’t handled by experienced ASC specialists. ClaimCare’s team has over 17 years of combined experience in medical billing and serves providers in all 50 states, including free-standing ASCs.
The company specializes in end-to-end claims management, denial follow-up, payer communications, and dashboard reporting. With real-time access to billing data, administrators have clearer visibility into revenue performance and outstanding claims. Their familiarity with ASC coding rules and payer requirements helps centers avoid common mistakes that lead to underpayments or delays.

| Best For | ASCs looking for experienced, full-cycle billing with broad payer knowledge |
|---|---|
| ASC Specialties Supported | Ambulatory Surgery Centers (multi-specialty) |
| Key Highlights |
|
| Founded In | 2003 |
6. Wise Medical Billing
Wise Medical Billing offers ambulatory surgery center (ASC) billing to address complex coding and claim challenges unique to ASCs. These challenges include the correct use of modifiers and benefit verification to avoid denials and under-payments. Their staff reviews ASC claims both manually and electronically to help ensure accurate coding and compliance with state and CMS guidelines.
Keeping up with changing compliance and coding updates is important for maximizing revenue. With a specialized team that is aware of ASC coding and compliance changes, claims are submitted correctly and on time. It is a key factor in avoiding denials that delay cash flow and increase administrative burden. Wise’s HIPAA-compliant processes and experienced billers help ASCs focus more on patient care rather than complex billing tasks.
| Best For | ASCs needing reliable billing support with structured RCM workflows | ASC Specialties Supported | Multi-specialty ambulatory surgery centers |
|---|---|
| Key Highlights |
|
| Founded In | 2022 |
7. Surgical Information Systems (SIS)
One of the most established names in the ASC, Surgical Information Systems (SIS), best known for its clinical software platform, also offers ASC billing services. A key differentiator is system-agnostic flexibility where they integrate with any existing ASC practice management software. Their billing services are backed by dedicated client service teams, billing managers, and business intelligence tools for cross-facility financial analysis.
On the compliance and security side, SIS holds both HIPAA and SOC 2 Type II certifications, with deep working knowledge of regulations. Practices see significant results, including monthly revenue increases, strong cash-to-net revenue ratios, and reductions in A/R days.

| Best For | ASCs seeking an enterprise-grade RCM partner with software and billing experience |
|---|---|
| ASC Specialties Supported | Multi-specialty ambulatory surgery centers |
| Key Highlights |
|
| Founded In | 1996 |
8. Sunshine Billing
Sunshine Billing is a medical billing provider that offers ambulatory surgery center (ASC) billing services. They assign certified medical billing specialists and account managers who handle everything from insurance verification, prior authorizations to denial follow-up and accounts receivable management. This reduces administrative burden for ASCs and helps ensure efficient claims processing.
With personalized attention through dedicated staff, they work with each client to tailor workflows and address unique practice needs. Their services also include ongoing reporting and payer communication, providing administrators with better visibility of outstanding claims. By managing the end-to-end billing process, Sunshine helps ASCs improve collections and streamline their revenue cycle.
| Best For | ASCs seeking full billing cycle support with dedicated specialists |
|---|---|
| ASC Specialties Supported | Multi-specialty surgery centers |
| Key Highlights |
|
| Founded In | 1999 |
9. in2itive Business Solutions
in2itive Business Solutions is a fully integrated RCM firm built exclusively for ambulatory surgery centers, combining ASC expertise with automation and AI analytics. Based in Overland Park, KS, their team operates directly within a center’s existing software. Their proprietary Account Management System serves as an intelligent workflow engine that guides claims from patient intake through final payment.
What sets in2itive apart is its analytics infrastructure. A platform powered by AI delivers predictive modeling, denial pattern trending, and payer performance benchmarking. This gives ASC administrators actionable financial intelligence rather than static reports. Their services extend beyond billing to include payer contract negotiation, fee schedule management, and A/R clean-up.
| Best For | ASCs seeking a technology-enabled, full-cycle RCM partner |
|---|---|
| ASC Specialties Supported | Multi-specialty ambulatory surgery centers |
| Key Highlights |
|
| Founded In | 2004 |
10. Altruis
Altruis provides specialized ambulatory surgery center (ASC) billing services designed to help outpatient surgery centers improve revenue performance. They support ASCs with comprehensive revenue cycle management and RetroPay services to recover underpayments or denied claims.
Altruis’ team focuses on expediting claim submissions, minimizing errors, and increasing reimbursements to maximize cash flow. With expertise in the complexities of ASC billing and a mission-driven approach, Altruis enables surgery centers to focus on patient care while optimizing their financial operations.

| Best For | ASCs seeking full-cycle revenue cycle management with a focus on maximizing reimbursements |
|---|---|
| ASC Specialties Supported | Multi-specialty ambulatory surgery centers |
| Key Highlights |
|
| Founded In | 2003 |
Conclusion
Choosing the right ASC billing partner is critical for ambulatory surgery centers looking to maximize reimbursements, reduce claim denials, and streamline revenue cycle operations. The companies listed above, from Transcure’s AI-enhanced full-service RCM to Altruis’s credentialing and RetroPay analysis, offer a range of solutions tailored to the unique needs of ASCs across the U.S.
By outsourcing billing to experts who understand ASC-specific coding, payer requirements, and compliance regulations, surgery centers can free internal staff and focus more on patient care. Selecting a partner that aligns with your specialty, volume, and operational goals ensures smoother revenue cycles for your surgery center.
How did our Editors Select the Top ASC Billing Companies?
We selected the top ASC billing companies by combining SERP analysis with criteria that reflect the operational complexity of ambulatory surgery centers. SERP research identified the companies that ASC administrators and surgery center directors are actively evaluating.
From there, we evaluated services, compliance, and pricing transparency. ASC-specific signals, including accurate facility-fee coding with CPT and HCPCS modifiers, adherence to the CMS ASC Covered Procedures List, and prior authorization workflows for high-acuity outpatient procedures, were assessed for each company.
Which is the Best ASC Billing Company in the USA?
Transcure is the best ASC billing company in the US. With AI-driven billing agents, a 99% clean claim rate, and over two decades of ASC-specific coding experience, Transcure consistently delivers 20%+ revenue improvement and reduces A/R by at least 30% within the first 90 days.
Which Are The Best Medical Billing Companies In The USA?
Across multiple specialties, Transcure tops the list of the best medical billing companies in the USA, followed by CBS Medical Billing & Consulting, Med USA, and Provider Care Billing. Transcure ranks first for its AI-powered denial prevention, ISO 27001-certified infrastructure, and coding depth across GI, orthopedics, ophthalmology, pain management, and ENT procedures.
Which ASC Practice Management Software Do Surgery Centers Use?
The five most widely used ASC EHR systems by ambulatory surgery centers are Provation, Surgical Information Systems, Procision EMR, VOZO EHR, and Picis. Provation dominates among independent and multi-specialty ASCs for its purpose-built financial workflows, while SIS is preferred in hospital-affiliated and enterprise surgery center settings. For a detailed comparison by case volume and specialty mix, read our guide to the best ASC practice management software.
How Can Surgery Centers Pick The Best ASC Billing Company?
When evaluating an ASC billing partner, start by confirming they have hands-on experience with facility-fee billing, not just professional-fee billing. Request performance benchmarks such as first-pass acceptance rates, denial rates by payer, and average A/R days. For high-volume ASCs, ask specifically how they handle CMS payment group assignments and implant/device billing.
Verify that their coders are AAPC- or AHIMA-certified with ASC-specific credentials. Confirm HIPAA compliance, CMS ASC regulatory alignment, and EHR/PM system integration capability. Clarify the fee structure. Also, ask for references from surgery centers with a comparable specialty and case mix.
Why does ASC billing require a separate claim submission from the operating surgeon?
ASCs bill under their own facility fee structure using UB-04 claims, entirely separate from the surgeon’s professional fee. If you’re new to the split-billing model, our ASC billing guide walks through exactly how each claim type is structured and submitted.
How do you apply modifier 73 vs. 74 for a discontinued ASC procedure?
Modifier 73 applies when a procedure is canceled after patient prep but before anesthesia; modifier 74 applies once anesthesia has been administered. The reimbursement difference is significant, and our ASC coding cheat sheet covers both with payer-specific notes.
How does outsourcing ASC billing improve revenue and compliance?
Outsourcing ASC billing improves coding accuracy, accelerates claim submission, strengthens denial management, and ensures compliance with CMS and payer-specific ASC regulations, resulting in faster reimbursements and reduced audit risk.



